Substitution in Amino Acid 70 of Hepatitis C Virus Core Protein Changes the Adipokine Profile via Toll-Like Receptor 2/4 Signaling

BACKGROUND & AIMS: It has been suggested that amino acid (aa) substitution at position 70 from arginine (70R) to glutamine (70Q) in the genotype 1b hepatitis C virus (HCV) core protein is associated with insulin resistance and worse prognosis. However, the precise mechanism is still unclear. The...

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Pubblicato in:PLoS One
Autori principali: Uraki, Satoko, Tameda, Masahiko, Sugimoto, Kazushi, Shiraki, Katsuya, Takei, Yoshiyuki, Nobori, Tsutomu, Ito, Masaaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487891/
https://ncbi.nlm.nih.gov/pubmed/26121241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131346
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