Selective enhancement of hypoxic cell killing by tempol-regulated suicide gene expression

The presence of hypoxic regions within solid tumors is caused by an imbalance between cell proliferation and angiogenesis. Such regions may facilitate the onset of recurrence after radiation therapy and chemotherapy, as hypoxic cells show resistance to these treatments. We found that tempol, a nitro...

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Bibliographic Details
Published in:Oncol Rep
Main Authors: KAGIYA, GO, OGAWA, RYOHEI, CHOUDHURI, RAJANI, COOK, JOHN A, HATASHITA, MASANORI, TANAKA, YOSHIKAZU, KODA, KANA, YAMASHITA, KEI, KUBO, MAKOTO, KAWAKAMI, FUMITAKA, MITCHELL, JAMES B
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487668/
https://ncbi.nlm.nih.gov/pubmed/26034980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2015.4020
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