iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis

INTRODUCTION: Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging disease. One of the main symptoms of this genetic disorder is a loss of sub-cutaneous fat du...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Mateos, Jesús, Landeira-Abia, Arancha, Fafián-Labora, Juan Antonio, Fernández-Pernas, Pablo, Lesende-Rodríguez, Iván, Fernández-Puente, Patricia, Fernández-Moreno, Mercedes, Delmiro, Aitor, Martín, Miguel A., Blanco, Francisco J., Arufe, María C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487579/
https://ncbi.nlm.nih.gov/pubmed/26066325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-015-0110-5
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