The cancer glycocalyx mechanically primes integrin-mediated growth and survival

Malignancy is associated with altered expression of glycans and glycoproteins that contribute to the cellular glycocalyx. We constructed a glycoprotein expression signature, which revealed that metastatic tumours upregulate expression of bulky glycoproteins. A computational model predicted that thes...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Paszek, Matthew J., DuFort, Christopher C., Rossier, Olivier, Bainer, Russell, Mouw, Janna K., Godula, Kamil, Hudak, Jason E., Lakins, Jonathon N., Wijekoon, Amanda C., Cassereau, Luke, Rubashkin, Matthew G., Magbanua, Mark J., Thorn, Kurt S., Davidson, Michael W., Rugo, Hope S., Park, John W., Hammer, Daniel A., Giannone, Grégory, Bertozzi, Carolyn R., Weaver, Valerie M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487551/
https://ncbi.nlm.nih.gov/pubmed/25030168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13535
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