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One cannot rule them all: Are bacterial toxins-antitoxins druggable?

Type II (proteic) toxin–antitoxin (TA) operons are widely spread in bacteria and archaea. They are organized as operons in which, usually, the antitoxin gene precedes the cognate toxin gene. The antitoxin generally acts as a transcriptional self-repressor, whereas the toxin acts as a co-repressor, b...

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Detalhes bibliográficos
Publicado no:FEMS Microbiol Rev
Main Authors: Chan, Wai Ting, Balsa, Dolors, Espinosa, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487406/
https://ncbi.nlm.nih.gov/pubmed/25796610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femsre/fuv002
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