Roscovitine in cancer and other diseases

Roscovitine [CY-202, (R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site. It is a broad-range purine inhibitor, which inhibits CDK1, CDK2, CDK5 and CDK7, but is a poor inhibitor for CDK4 and CDK6. Roscoviti...

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Detalhes bibliográficos
Publicado no:Ann Transl Med
Main Authors: Cicenas, Jonas, Kalyan, Karthik, Sorokinas, Aleksandras, Stankunas, Edvinas, Levy, Josh, Meskinyte, Ingrida, Stankevicius, Vaidotas, Kaupinis, Algirdas, Valius, Mindaugas
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2015
Assuntos:
Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486920/
https://ncbi.nlm.nih.gov/pubmed/26207228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2305-5839.2015.03.61
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