Small molecule, NSC95397, inhibits the CtBP1-protein partner interaction and CtBP1-mediated transcriptional repression

Carboxyl-terminal binding protein (CtBP) is a transcriptional co-repressor that suppresses multiple pro-apoptotic and epithelial genes. CtBP is overexpressed in many human cancers and its overexpression increases stem cell-like features, epithelial-mesenchymal transition, and cancer cell survival. K...

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Veröffentlicht in:J Biomol Screen
Hauptverfasser: Blevins, Melanie A., Kouznetsova, Jennifer, Krueger, Aaron B., King, Rebecca, Griner, Lesley Mathews, Hu, Xin, Southall, Noel, Marugan, Juan J., Zhang, Qinghong, Ferrer, Marc, Zhao, Rui
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486263/
https://ncbi.nlm.nih.gov/pubmed/25477201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114561400
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