Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases

Suppressor of cytokine signalling 2 (SOCS2) is the substrate-binding component of a Cullin-RING E3 ubiquitin ligase (CRL) complex that targets phosphorylated hormone receptors for degradation by the ubiquitin-proteasome system. As a key regulator of the transcriptional response to growth signals, SO...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Gadd, Morgan S., Bulatov, Emil, Ciulli, Alessio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486172/
https://ncbi.nlm.nih.gov/pubmed/26121586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131218
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