A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors

BACKGROUND: Ovarian granulosa cell tumors are the most common sex-cord stromal tumors and have juvenile (JGCTs) and adult forms. In a previous study we reported the occurrence of activating somatic mutations of Gαs, which transduces mitogenic signals, in 30% of the analyzed JGCTs. METHODS: We have s...

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Publicado en:EBioMedicine
Autores principales: Bessière, Laurianne, Todeschini, Anne-Laure, Auguste, Aurélie, Sarnacki, Sabine, Flatters, Delphine, Legois, Bérangère, Sultan, Charles, Kalfa, Nicolas, Galmiche, Louise, Veitia, Reiner A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485906/
https://ncbi.nlm.nih.gov/pubmed/26137586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.03.002
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