P16 Methylation as an Early Predictor for Cancer Development From Oral Epithelial Dysplasia: A Double-blind Multicentre Prospective Study

BACKGROUND: Silencing of P16 through methylation and locus deletion is the most frequent early events in carcinogenesis. The aim of this study is to prospectively determine if early P16 methylation is a predictor for oral cancer development. METHODS: Patients (n = 181) with mild or moderate oral epi...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Liu, Hongwei, Liu, Xue-wei, Dong, Guangying, Zhou, Jing, Liu, Yang, Gao, Yan, Liu, Xiao-yong, Gu, Liankun, Sun, Zheng, Deng, Dajun
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485905/
https://ncbi.nlm.nih.gov/pubmed/26137587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.03.015
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