Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

BACKGROUND: Triptolide is a therapeutic diterpenoid derived from the Chinese herb Tripterygium wilfordii Hook f. Triptolide has been shown to induce apoptosis by activation of pro-apoptotic proteins, inhibiting NFkB and c-KIT pathways, suppressing the Jak2 transcription, activating MAPK8/JNK signali...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: Chauhan, Lata, Jenkins, Gregory D., Bhise, Neha, Feldberg, Tanya, Mitra-Ghosh, Taraswi, Fridley, Brooke L., Lamba, Jatinder K.
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485866/
https://ncbi.nlm.nih.gov/pubmed/26121980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1614-1
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