NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization

Early stage growth of intracranial B16F10 tumors is reduced by 87% in myeloid-specific NG2 null (Mac-NG2ko) mice and by 77% in pericyte-specific NG2 null (PC-NG2ko) mice, demonstrating the importance of the NG2 proteoglycan in each of these stromal compartments. In both genotypes, loss of pericyte-e...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Yotsumoto, Fusanori, You, Weon-Kyoo, Cejudo-Martin, Pilar, Kucharova, Karolina, Sakimura, Kenji, Stallcup, William B
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485789/
https://ncbi.nlm.nih.gov/pubmed/26137396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2014.1001204
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