Epstein-Barr virus-induced gene 3-deficiency leads to impaired antitumor T-cell responses and accelerated tumor growth

Epstein-Barr virus-induced gene 3 (EBI3) encoded protein can form heterodimers with IL-27P28, and IL-12P35 to form IL-27, and IL-35. However, IL-27 stimulates, whereas IL-35 inhibits antitumor T-cell responses. IL-27 also limits the Foxp3(+) regulatory T cell (Treg) population, whereas IL-35 has bee...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Liu, Zhenzhen, Liu, Jin-Qing, Shi, Yun, Zhu, Xiaotong, Liu, Zhihao, Li, Ming-Song, Yu, Jianhua, Wu, Lai-Chu, He, Yukai, Zhang, Guoqiang, Bai, Xue-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485763/
https://ncbi.nlm.nih.gov/pubmed/26140252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.989137
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