Repeated intratumoral administration of ONCOS-102 leads to systemic antitumor CD8(+) T-cell response and robust cellular and transcriptional immune activation at tumor site in a patient with ovarian cancer

Adenoviruses are excellent immunotherapeutic agents with a unique ability to prime and boost immune responses. Recombinant adenoviruses cause immunogenic cancer cell death and subsequent release of tumor antigens for antigen presenting cells, resulting in the priming of potent tumor-specific immunit...

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Bibliografische gegevens
Gepubliceerd in:Oncoimmunology
Hoofdauteurs: Vassilev, L, Ranki, T, Joensuu, T, Jäger, E, Karbach, J, Wahle, C, Partanen, K, Kairemo, K, Alanko, T, Turkki, R, Linder, N, Lundin, J, Ristimäki, A, Kankainen, M, Hemminki, A, Backman, C, Dienel, K, von Euler, M, Haavisto, E, Hakonen, T, Juhila, J, Jäderberg, M, Priha, P, Vuolanto, A, Pesonen, S
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2015
Onderwerpen:
Brief Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485730/
https://ncbi.nlm.nih.gov/pubmed/26140248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1017702
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