Hyperglycemia increases the expression levels of sclerostin in a reactive oxygen species- and tumor necrosis factor-alpha-dependent manner

PURPOSE: Sclerostin, an inhibitor of Wnt/β-catenin signaling, exerts negative effects on bone formation and contributes to periodontitis-induced alveolar bone loss. Recent studies have demonstrated that serum sclerostin levels are increased in diabetic patients and that sclerostin expression in alve...

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Bibliografske podrobnosti
izdano v:J Periodontal Implant Sci
Main Authors: Kang, Jiho, Boonanantanasarn, Kanitsak, Baek, Kyunghwa, Woo, Kyung Mi, Ryoo, Hyun-Mo, Baek, Jeong-Hwa, Kim, Gwan-Shik
Format: Artigo
Jezik:Inglês
Izdano: Korean Academy of Periodontology 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485060/
https://ncbi.nlm.nih.gov/pubmed/26131370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5051/jpis.2015.45.3.101
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