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Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH
We report here a nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands. Due to ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (< 6.5). The particle uptake and cytotoxicity increases over this pH range. This pH-controlle...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4484729/ https://ncbi.nlm.nih.gov/pubmed/25873209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411615 |
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