Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

We provide first-time evidence for ERβ-mediated transcriptional upregulation of c-FLIP as an underlying mechanism in the development of castrate-resistant cancer. While androgens inhibit apoptosis partly through transcriptional upregulation of the anti-apoptotic protein, c-FLIP in androgen-responsiv...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Yun, Huiyoung, Xie, Jianping, Olumi, Aria F., Ghosh, Rita, Kumar, Addanki P.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484479/
https://ncbi.nlm.nih.gov/pubmed/25816367
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