Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway

Chondrosarcoma is a malignant tumor that produces cartilage matrix. The most lethal aspect is its metastatic property. We demonstrated that amphiregulin (AR) is significantly upregulated in highly aggressive cells. AR silencing markedly suppressed cell migration. Exogenous AR markedly increased cell...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chen, Jui-Chieh, Chen, Yu-Ju, Lin, Chih-Yang, Fong, Yi-Chin, Hsu, Chin-Jung, Tsai, Chun-Hao, Su, Jen-Liang, Tang, Chih-Hsin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484467/
https://ncbi.nlm.nih.gov/pubmed/25825984
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