Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway

Chondrosarcoma is a malignant tumor that produces cartilage matrix. The most lethal aspect is its metastatic property. We demonstrated that amphiregulin (AR) is significantly upregulated in highly aggressive cells. AR silencing markedly suppressed cell migration. Exogenous AR markedly increased cell...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Chen, Jui-Chieh, Chen, Yu-Ju, Lin, Chih-Yang, Fong, Yi-Chin, Hsu, Chin-Jung, Tsai, Chun-Hao, Su, Jen-Liang, Tang, Chih-Hsin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484467/
https://ncbi.nlm.nih.gov/pubmed/25825984
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