Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

Large oncosomes (LO) are atypically large (1-10μm diameter) cancer-derived extracellular vesicles (EVs), originating from the shedding of membrane blebs and associated with advanced disease. We report that 25% of the proteins, identified by a quantitative proteomics analysis, are differentially repr...

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Publicat a:Oncotarget
Autors principals: Minciacchi, Valentina R., You, Sungyong, Spinelli, Cristiana, Morley, Samantha, Zandian, Mandana, Aspuria, Paul-Joseph, Cavallini, Lorenzo, Ciardiello, Chiara, Sobreiro, Mariana Reis, Morello, Matteo, Kharmate, Geetanjali, Jang, Su Chul, Kim, Dae-Kyum, Hosseini-Beheshti, Elham, Guns, Emma Tomlinson, Gleave, Martin, Gho, Yong Song, Mathivanan, Suresh, Yang, Wei, Freeman, Michael R., Di Vizio, Dolores
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484459/
https://ncbi.nlm.nih.gov/pubmed/25857301
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