Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Epithelial Ovarian Cancer (EOC) “cholinic phenotype”, characterized by increased intracellular phosphocholine content sustained by over-expression/activity of choline kinase-alpha (ChoKα/CHKA), is a metabolic cellular reprogramming involved in chemoresistance with still unknown mechanisms. By stable...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Granata, Anna, Nicoletti, Roberta, Perego, Paola, Iorio, Egidio, Krishnamachary, Balaji, Benigni, Fabio, Ricci, Alessandro, Podo, Franca, Bhujwalla, Zaver M., Canevari, Silvana, Bagnoli, Marina, Mezzanzanica, Delia
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484451/
https://ncbi.nlm.nih.gov/pubmed/25796169
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