RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer

We have demonstrated that RNA-dependent protein kinase (PKR) and its downstream protein p-eIF2α are independent prognostic markers for overall survival in lung cancer. In the current study, we further investigate the interaction between PKR and AMPK in lung tumor tissue and cancer cell lines. We exa...

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Vydáno v:Oncotarget
Hlavní autoři: Guo, Chengcheng, Hao, Chuncheng, Shao, RuPing, Fang, Bingliang, Correa, Arlene M., Hofstetter, Wayne L., Roth, Jack A., Behrens, Carmen, Kalhor, Neda, Wistuba, Ignacio I., Swisher, Stephen G., Pataer, Apar
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484443/
https://ncbi.nlm.nih.gov/pubmed/25798539
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