RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer

We have demonstrated that RNA-dependent protein kinase (PKR) and its downstream protein p-eIF2α are independent prognostic markers for overall survival in lung cancer. In the current study, we further investigate the interaction between PKR and AMPK in lung tumor tissue and cancer cell lines. We exa...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guo, Chengcheng, Hao, Chuncheng, Shao, RuPing, Fang, Bingliang, Correa, Arlene M., Hofstetter, Wayne L., Roth, Jack A., Behrens, Carmen, Kalhor, Neda, Wistuba, Ignacio I., Swisher, Stephen G., Pataer, Apar
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484443/
https://ncbi.nlm.nih.gov/pubmed/25798539
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