Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

Pygopus-2 over-expression has been reported in several malignancies, such as ovarian, breast, lung and liver cancers. Here we demonstrated that down-regulation of Pygopus-2 by shRNA inhibited hepatic carcinoma cell invasion in vitro and metastasis in xenograft tumor models, which were promoted when...

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Pubblicato in:Oncotarget
Autori principali: Zhang, Sheng, Li, Jie, Liu, Pingguo, Xu, Jianfeng, Zhao, Wenxiu, Xie, Chengrong, Yin, Zhenyu, Wang, Xiaomin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484440/
https://ncbi.nlm.nih.gov/pubmed/25871475
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