Construction of Escherichia coli Mutant with Decreased Endotoxic Activity by Modifying Lipid A Structure

Escherichia coli BL21 (DE3) and its derivatives are widely used for the production of recombinant proteins, but these purified proteins are always contaminated with lipopolysaccharide (LPS). LPS is recognized by the toll-like receptor 4 and myeloid differentiation factor 2 complex of mammalian immun...

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Veröffentlicht in:Mar Drugs
Hauptverfasser: Liu, Qiong, Li, Yanyan, Zhao, Xinxin, Yang, Xue, Liu, Qing, Kong, Qingke
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483635/
https://ncbi.nlm.nih.gov/pubmed/26023843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13063388
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