Classical natural ovine scrapie prions detected in practical volumes of blood by lamb and transgenic mouse bioassays

Scrapie is diagnosed antemortem in sheep by detecting misfolded isoforms of prion protein (PrP(Sc)) in lymphoid follicles of the rectal mucosa and nictitating membranes. Assay sensitivity is limited if (a) the biopsy is collected early during disease development, (b) an insufficient number of follic...

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Detalhes bibliográficos
Publicado no:J Vet Sci
Main Authors: Dassanayake, Rohana P., Truscott, Thomas C., Zhuang, Dongyue, Schneider, David A., Madsen-Bouterse, Sally A., Young, Alan J., Stanton, James B., Davis, William C., O'Rourke, Katherine I.
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Veterinary Science 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483501/
https://ncbi.nlm.nih.gov/pubmed/25549221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4142/jvs.2015.16.2.179
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