Improved Natural Killer cell activity and retained anti-tumor CD8(+) T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy

BACKGROUND: Locally advanced HER2-overexpressing breast cancer (BC) patients achieve a high rate of pathological complete responses (pCR) after neoadjuvant chemotherapy (NC). The apparently unaltered immune proficiency of these patients together with the immune-modulating activities of NC drugs sugg...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Muraro, E, Comaro, E, Talamini, R, Turchet, E, Miolo, G, Scalone, S, Militello, L, Lombardi, D, Spazzapan, S, Perin, T, Massarut, S, Crivellari, D, Dolcetti, Riccardo, Martorelli, D
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483222/
https://ncbi.nlm.nih.gov/pubmed/26116238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0567-0
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