Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children

BACKGROUND: Aurora Kinase A (AURKA) encodes a protein that regulates the formation and stability of the mitotic spindle and is highly active in atypical teratoid rhabdoid tumors (ATRT) through loss of the INI1 tumor suppressor gene. Alisertib (MLN8237) inhibits AURKA in vitro and in vivo. Given the...

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Foilsithe in:Neuro Oncol
Main Authors: Wetmore, Cynthia, Boyett, James, Li, Shaoyu, Lin, Tong, Bendel, Anne, Gajjar, Amar, Orr, Brent A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2015
Ábhair:
Pediatric Neuro-Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483126/
https://ncbi.nlm.nih.gov/pubmed/25688119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov017
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