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Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children
BACKGROUND: Aurora Kinase A (AURKA) encodes a protein that regulates the formation and stability of the mitotic spindle and is highly active in atypical teratoid rhabdoid tumors (ATRT) through loss of the INI1 tumor suppressor gene. Alisertib (MLN8237) inhibits AURKA in vitro and in vivo. Given the...
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| Gepubliceerd in: | Neuro Oncol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4483126/ https://ncbi.nlm.nih.gov/pubmed/25688119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov017 |
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