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Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes

High rates of error-prone replication result in the rapid accumulation of genetic diversity of RNA viruses. Recent studies suggest that mutation rates are selected for optimal viral fitness and that modest variations in replicase fidelity may be associated with viral attenuation. Arthropod-borne vir...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Van Slyke, Greta A., Arnold, Jamie J., Lugo, Alex J., Griesemer, Sara B., Moustafa, Ibrahim M., Kramer, Laura D., Cameron, Craig E., Ciota, Alexander T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482725/
https://ncbi.nlm.nih.gov/pubmed/26114757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005009
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