Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development

BACKGROUND: In this study, a Burkholderia mallei tonB mutant (TMM001) deficient in iron acquisition was constructed, characterized, and evaluated for its protective properties in acute inhalational infection models of murine glanders and melioidosis. METHODOLOGY/PRINCIPAL FINDINGS: Compared to the w...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Mott, Tiffany M., Vijayakumar, Sudhamathi, Sbrana, Elena, Endsley, Janice J., Torres, Alfredo G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482651/
https://ncbi.nlm.nih.gov/pubmed/26114445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003863
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