Cortical and Subcortical Grey and White Matter Atrophy in Myotonic Dystrophies Type 1 and 2 Is Associated with Cognitive Impairment, Depression and Daytime Sleepiness

OBJECTIVES: Central nervous system involvement is one important clinical aspect of myotonic dystrophy type 1 and 2 (DM1 and DM2). We assessed CNS involvement DM1 and DM2 by 3T MRI and correlated clinical and neuocognitive symptoms with brain volumetry and voxel-based morphometry (VBM). METHODS: 12 p...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schneider-Gold, Christiane, Bellenberg, Barabara, Prehn, Christian, Krogias, Christos, Schneider, Ruth, Klein, Jan, Gold, Ralf, Lukas, Carsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482602/
https://ncbi.nlm.nih.gov/pubmed/26114298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130352
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