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A Novel Feedback Loop That Controls Bimodal Expression of Genetic Competence

Gene expression can be highly heterogeneous in isogenic cell populations. An extreme type of heterogeneity is the so-called bistable or bimodal expression, whereby a cell can differentiate into two alternative expression states. Stochastic fluctuations of protein levels, also referred to as noise, p...

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Pubblicato in:PLoS Genet
Autori principali: Gamba, Pamela, Jonker, Martijs J., Hamoen, Leendert W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482431/
https://ncbi.nlm.nih.gov/pubmed/26110430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005047
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