The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade

INTRODUCTION: The cytokines interleukin (IL)-7 and thymic stromal lymphopoietin (TSLP) signal through the IL-7R subunit and play proinflammatory roles in experimental arthritis and rheumatoid arthritis (RA). We evaluated the effect of inhibition of IL-7R- and TSLPR-signalling as well as simultaneous...

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Publicado en:PLoS One
Autores principales: Hillen, Maarten R., Hartgring, Sarita A. Y., Willis, Cynthia R., Radstake, Timothy R. D. J., Hack, Cornelis E., Lafeber, Floris P. J. G., van Roon, Joel A. G
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482403/
https://ncbi.nlm.nih.gov/pubmed/26110994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130830
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