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Characterization of SMAD3 Gene Variants for Possible Roles in Ventricular Septal Defects and Other Congenital Heart Diseases

BACKGROUND: Nodal/TGF signaling pathway has an important effect at early stages of differentiation of human embryonic stem cells in directing them to develop into different embryonic lineages. SMAD3 is a key intracellular messenger regulating factor in the Nodal/TGF signaling pathway, playing import...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Fei-Feng, Zhou, Jing, Zhao, Dan-Dan, Yan, Peng, Li, Xia, Han, Ying, Li, Xian-Shu, Wang, Gui-Yu, Yu, Kai-Jiang, Liu, Shu-Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482402/
https://ncbi.nlm.nih.gov/pubmed/26110764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131542
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