Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced parkinsonism

Background Dopamine (DA) neuron-selective uptake and toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes parkinsonism in humans. Loss of DA neurons via mitochondrial damage and oxidative stress is reproduced by systemic injection of MPTP in animals, which serves as models of parki...

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Bibliografiske detaljer
Udgivet i:F1000Res
Main Authors: Kitao, Yasuko, Ageta-Ishihara, Natsumi, Takahashi, Ryosuke, Kinoshita, Makoto, Hori, Osamu
Format: Artigo
Sprog:Inglês
Udgivet: F1000Research 2015
Fag:
Research Note
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482211/
https://ncbi.nlm.nih.gov/pubmed/26167274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.6386.1
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