Preoperative Single-Fraction Partial Breast Radiotherapy – A Novel Phase I Dose-Escalation Protocol with Radiation Response Biomarkers

This phase I dose-escalation trial evaluates the feasibility of single-dose preoperative partial breast irradiation delivered with external beam techniques in early stage breast cancer patients. No acute dose-limiting toxicity was observed at 15, 18, or 21Gy. Paired pre- and post-radiation imaging a...

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Veröffentlicht in:Int J Radiat Oncol Biol Phys
Hauptverfasser: Horton, Janet K., Blitzblau, Rachel C., Yoo, Sua, Geradts, Joseph, Chang, Zheng, Baker, Jay A., Georgiade, Gregory S., Chen, Wei, Siamakpour-Reihani, Sharareh, Wang, Chunhao, Broadwater, Gloria, Groth, Jeff, Palta, Manisha, Dewhirst, Mark, Barry, William T., Duffy, Eileen A., Chi, Jen-Tsan A., Hwang, E. Shelley
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481883/
https://ncbi.nlm.nih.gov/pubmed/26104938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2015.03.007
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