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Closed and Semiclosed Interhelical Structures in Membrane vs Closed and Open Structures in Detergent for the Influenza Virus Hemagglutinin Fusion Peptide and Correlation of Hydrophobic Surface Area with Fusion Catalysis

The ~25 N-terminal “HAfp” residues of the HA2 subunit of the influenza virus hemagglutinin protein are critical for fusion between the viral and endosomal membranes at low pH. Earlier studies of HAfp in detergent support (1) N-helix/turn/C-helix structure at pH 5 with open interhelical geometry and...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Ghosh, Ujjayini, Xie, Li, Jia, Lihui, Liang, Shuang, Weliky, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481145/
https://ncbi.nlm.nih.gov/pubmed/26039158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04578
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