HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

Granulocytes and monocytes/macrophages of the myeloid lineage are the chief cellular agents of innate immunity. Here, we have examined the inflammatory response in mice with conditional knockouts of the hypoxia responsive transcription factor HIF-1α, its negative regulator VHL, and a known downstrea...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Cramer, Thorsten, Yamanishi, Yuji, Clausen, Björn E., Förster, Irmgard, Pawlinski, Rafal, Mackman, Nigel, Haase, Volker H., Jaenisch, Rudolf, Corr, Maripat, Nizet, Victor, Firestein, Gary S., Gerber, Hans-Peter, Ferrara, Napoleone, Johnson, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480774/
https://ncbi.nlm.nih.gov/pubmed/12628185
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