Anti-tumour effects of antibodies targeting the extracellular cysteine-rich region of the receptor tyrosine kinase EphB4

EphB4 is a membrane-bound receptor tyrosine kinase (RTK) commonly over-produced by many epithelial cancers but with low to no expression in most normal adult tissues. EphB4 over-production promotes ligand-independent signaling pathways that increase cancer cell viability and stimulate migration and...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Stephenson, Sally-Anne, Douglas, Evelyn L., Mertens-Walker, Inga, Lisle, Jessica E., Maharaj, Mohanan S.N., Herington, Adrian C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4480699/
https://ncbi.nlm.nih.gov/pubmed/25831049
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