Favorable Alteration of Tumor Microenvironment by Immunomodulatory Cytokines for Efficient T-Cell Therapy in Solid Tumors

Unfavorable ratios between the number and activation status of effector and suppressor immune cells infiltrating the tumor contribute to resistance of solid tumors to T-cell based therapies. Here, we studied the capacity of FDA and EMA approved recombinant cytokines to manipulate this balance in fav...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tähtinen, Siri, Kaikkonen, Saija, Merisalo-Soikkeli, Maiju, Grönberg-Vähä-Koskela, Susanna, Kanerva, Anna, Parviainen, Suvi, Vähä-Koskela, Markus, Hemminki, Akseli
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479879/
https://ncbi.nlm.nih.gov/pubmed/26107883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131242
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