AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial

BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are key drivers of this mortality. Novel tr...

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Dades bibliogràfiques
Publicat a:Trials
Autors principals: Molefi, Mooketsi, Chofle, Awilly A., Molloy, Síle F., Kalluvya, Samuel, Changalucha, John M., Cainelli, Francesca, Leeme, Tshepo, Lekwape, Nametso, Goldberg, Drew W., Haverkamp, Miriam, Bisson, Gregory P., Perfect, John R., Letang, Emili, Fenner, Lukas, Meintjes, Graeme, Burton, Rosie, Makadzange, Tariro, Ndhlovu, Chiratidzo E., Hope, William, Harrison, Thomas S., Jarvis, Joseph N.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Study Protocol
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479349/
https://ncbi.nlm.nih.gov/pubmed/26081985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0799-6
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