AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial

BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are key drivers of this mortality. Novel tr...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Molefi, Mooketsi, Chofle, Awilly A., Molloy, Síle F., Kalluvya, Samuel, Changalucha, John M., Cainelli, Francesca, Leeme, Tshepo, Lekwape, Nametso, Goldberg, Drew W., Haverkamp, Miriam, Bisson, Gregory P., Perfect, John R., Letang, Emili, Fenner, Lukas, Meintjes, Graeme, Burton, Rosie, Makadzange, Tariro, Ndhlovu, Chiratidzo E., Hope, William, Harrison, Thomas S., Jarvis, Joseph N.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479349/
https://ncbi.nlm.nih.gov/pubmed/26081985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-015-0799-6
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