Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration

INTRODUCTION: Cytoplasmic TDP-43 inclusions are the pathological hallmark of amyotrophic lateral sclerosis (ALS) and tau-negative frontotemporal lobar dementia (FTLD). The G(4)C(2) repeat mutation in C9ORF72 is the most common cause of ALS and FTLD in which, in addition to TDP-43 inclusions, five di...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Acta Neuropathol Commun
Hlavní autoři: Gomez-Deza, Jorge, Lee, Youn-bok, Troakes, Claire, Nolan, Matthew, Al-Sarraj, Safa, Gallo, Jean-Marc, Shaw, Christopher E.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479315/
https://ncbi.nlm.nih.gov/pubmed/26108573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0218-y
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky