Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients

BACKGROUND: The mevalonate pathway synthetizes cholesterol, steroid hormones, and non-steriod isoprenoids necessary for cell survival. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme of the mevalonate pathway and the target for statin treatment. HMGCR expression i...

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Vydáno v:BMC Clin Pathol
Hlavní autoři: Gustbée, Emma, Tryggvadottir, Helga, Markkula, Andrea, Simonsson, Maria, Nodin, Björn, Jirström, Karin, Rose, Carsten, Ingvar, Christian, Borgquist, Signe, Jernström, Helena
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479235/
https://ncbi.nlm.nih.gov/pubmed/26109908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12907-015-0008-2
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