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High yield and high specific activity synthesis of [(18)F]Fallypride in a batch microfluidic reactor for micro-PET imaging

[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65±6% (n=7) and an average specific activity of 730 GBq/μmol (20 Ci/μmol) (n=4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized on a macroscale radiosynthesizer, despite starting wit...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Javed, Muhammad Rashed, Chen, Supin, Lei, Jack, Collins, Jeffrey, Sergeev, Maxim, Kim, Hee-Kwon, Kim, Chang-Jin, van Dam, R. Michael, Keng, Pei Yuin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479166/
https://ncbi.nlm.nih.gov/pubmed/24326303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc47616b
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