One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge.

We have created four IgG3 mutants without a normal hinge region: (i) m0 without a genetic hinge; (ii) m0/C131S, where Cys-131 in m0 was mutated to Ser; (iii) m0/231C232 (formerly HM-1), where a Cys residue was inserted in m0 between Ala-231 and Pro-232; (iv) m0/C131S/231C232, which is a hybrid of m0...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Michaelsen, T E, Brekke, O H, Aase, A, Sandin, R H, Bremnes, B, Sandlie, I
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44788/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7937748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.20.9243
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