A Combination of Three Fully Human Toxin A- and Toxin B-Specific Monoclonal Antibodies Protects against Challenge with Highly Virulent Epidemic Strains of Clostridium difficile in the Hamster Model

Clostridium difficile infection (CDI) is the principal cause of nosocomial diarrhea and pseudomembranous colitis associated with antibiotic therapy. Recent increases in the number of outbreaks attributed to highly virulent antibiotic-resistant strains underscore the importance of identifying efficac...

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Detalhes bibliográficos
Publicado no:Clin Vaccine Immunol
Main Authors: Anosova, Natalie G., Cole, Leah E., Li, Lu, Zhang, Jinrong, Brown, Anna M., Mundle, Sophia, Zhang, Jianxin, Ray, Satyajit, Ma, Fuqin, Garrone, Pierre, Bertraminelli, Nicola, Kleanthous, Harry, Anderson, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478530/
https://ncbi.nlm.nih.gov/pubmed/25924765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00763-14
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