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Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell Phenotypes
We have shown that in cattle previously immunized with outer membrane proteins, infection with Anaplasma marginale induces a functionally exhausted CD4 T-cell response to the A. marginale immunogen. Furthermore, T-cell responses following infection in nonimmunized cattle had a delayed onset and were...
Shranjeno v:
izdano v: | Clin Vaccine Immunol |
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Main Authors: | , , , , , , , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
American Society for Microbiology
2015
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4478516/ https://ncbi.nlm.nih.gov/pubmed/25924762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00168-15 |
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