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Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell Phenotypes

We have shown that in cattle previously immunized with outer membrane proteins, infection with Anaplasma marginale induces a functionally exhausted CD4 T-cell response to the A. marginale immunogen. Furthermore, T-cell responses following infection in nonimmunized cattle had a delayed onset and were...

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Bibliografske podrobnosti
izdano v:Clin Vaccine Immunol
Main Authors: Brown, Wendy C., Turse, Joshua E., Lawrence, Paulraj K., Johnson, Wendell C., Scoles, Glen A., Deringer, James R., Sutten, Eric L., Han, Sushan, Norimine, Junzo
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478516/
https://ncbi.nlm.nih.gov/pubmed/25924762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00168-15
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