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CDK5 targeting prevents β-amyloid aggregation involving GSK3 β and phosphatases
Inappropriate activation of CDK5 due to proteolytic release of the activator fragment p25 from the membrane contributes to the formation of neurofibrillary tangles, β-amyloid aggregation and chronic neurodegeneration. At 18 months of age, 3xTg-AD mice were sacrificed after either three weeks (short-...
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| Vydáno v: | J Neurosci Res |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4478163/ https://ncbi.nlm.nih.gov/pubmed/25711385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.23576 |
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