Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease

Disease recurrence after allogeneic hematopoietic cell transplant (alloHCT) remains common, making improvements in conditioning regimens desirable. A dose-response relationship between busulfan exposure and outcome is known. Using individual real-time monitoring of the busulfan area under the curve...

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Publicado no:Leuk Lymphoma
Main Authors: O’DONNELL, PETER H., ARTZ, ANDREW S., UNDEVIA, SAMIR D., PAI, RISH K., CERRO, PAULA DEL, HOROWITZ, SARAH, GODLEY, LUCY A., HART, JOHN, INNOCENTI, FEDERICO, LARSON, RICHARD A., ODENIKE, OLATOYOSI M., STOCK, WENDY, VAN BESIEN, KOEN
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477684/
https://ncbi.nlm.nih.gov/pubmed/20919852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2010.520773
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