Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4)

Ring finger protein 4 (RNF4) is a SUMO-targeted ubiquitin E3 ligase with a pivotal function in the DNA damage response (DDR). SUMO interaction motifs (SIMs) in the N-terminal part of RNF4 tightly bind to SUMO polymers, and RNF4 can ubiquitinate these polymers in vitro. Using a proteomic approach, we...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Hendriks, Ivo A., Schimmel, Joost, Eifler, Karolin, Olsen, Jesper V., Vertegaal, Alfred C. O.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477612/
https://ncbi.nlm.nih.gov/pubmed/25969536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618132
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