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Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes
Aneuploidy in human eggs is the leading cause of pregnancy loss and several genetic disorders such as Down’s syndrome. Most aneuploidy results from chromosome segregation errors during the meiotic divisions of an oocyte, the egg’s progenitor cell. The basis for particularly error-prone chromosome se...
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| Pubblicato in: | Science |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4477045/ https://ncbi.nlm.nih.gov/pubmed/26045437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa9529 |
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