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A Synthesis of Alsmaphorazine B Demonstrates the Chemical Feasibility of a New Biogenetic Hypothesis

An N-oxide fragmentation/hydroxylamine oxidation/intramolecular 1,3-dipolar cycloaddition cascade efficiently converted an oxidized congener of akuammicine into the complex, hexacyclic architecture of the alsmaphorazine alkaloids. This dramatic structural change shows the chemical feasibility of our...

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Publicat a:J Am Chem Soc
Autors principals: Hong, Allen Y., Vanderwal, Christopher D.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477012/
https://ncbi.nlm.nih.gov/pubmed/26034815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04686
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